No more boosters? How an army pan-coronavirus vaccine could wipe out COVID pandemics – Archyde

The Army’s COVID vaccine entered Phase 1 human trials in March 2021.

Sergeant Tanis Kilgore/US-Armee

the Omicron variant of COVID-19 has led to a surge in cases and hospitalizations, prompting medical experts to discuss the annual COVID Booster Shots and variant-specific vaccines. But what if there was a universal coronavirus vaccine that protected against Omicron and all new COVID-19 variants?

Several institutions conduct research “Pan-coronavirus” vaccines, and major health organizations are vocal about the need, but the US Army is the first to report positive trial results for a universal coronavirus vaccine.

the Army recently announced that its pan-coronavirus vaccine, Spike Ferritin Nanoparticles COVID-19 vaccine (aka SpFN), had completed Phase 1 human trials. The results are expected to be released in January depending on the completion of the official data analysis.

dr Kayvon Modjarrad, director of infectious diseases at the Walter Reed Army Institute of Research (WRAIR) and co-inventor of SpFN, said defense one“We’re testing our vaccine against all the different variants, including Omicron,” the strain cause breakthrough infections also in people who have received booster vaccinations.

We share what we know about pan-coronavirus vaccines and the Army’s COVID-19 vaccine, including how it works and when it might be available.

For more information, see free at-home COVID tests, why shouldn’t you”Just get COVID over with,” mix and match Booster Shots, and the Difference between N95, KN95 and KF94 masks.

Why do we need a pan-coronavirus vaccine?

White House Medical Advisor Dr. Anthony Fauci, recently touted the importance of a universal vaccine to protect against all COVID variants. At a Press conference at the White House on WednesdayFauci reiterated “the urgent need for a universal coronavirus vaccine.”

Fauci stated that “innovative approaches are needed to achieve broad and durable protection against known and some as yet unknown coronaviruses. Hence the terminology ‘pan-coronavirus vaccine’.”

The National Institute of Allergy and Infectious Diseases has made a strong commitment to this goal in Fall 2021. Awarded $36.3 million to three academic organizations – Duke University, University of Wisconsin and Boston’s Brigham and Women’s Hospital – to develop and research pan-coronavirus vaccines. CalTech also announced good early results for its universal “mosaic nanoparticle” vaccine.

In an advisory statement dated January 11 on the omicron variant, the World Health Organization explained that “a vaccination strategy based on repeated booster doses of the original vaccine composition is unlikely to be appropriate or sustainable,” stressing the urgent need for a vaccine that provides long-lasting protection without a booster.

What is the US Army’s COVID vaccine?

The three COVID-19 vaccines currently approved for use in the United States take two approaches to preventing infection: the Pfizer and Moderna vaccines mRNA to build immunity, while Johnson & Johnson’s vaccine uses a harmless rhinovirus to train the body’s immune system to respond to COVID.

The spike-ferritin nanoparticle COVID-19 vaccine, or SpFN, takes a third approach, using a harmless part of the COVID-19 virus to stimulate the body’s defenses against COVID.

SpFN also has less restrictive storage and handling requirements than the Moderna and Pfizer vaccines, allowing it to be used in a greater variety of situations. It can be stored between 36 and 46 degrees Fahrenheit for up to six months and at room temperature for up to one month. according to military scientists. Pfizer’s vaccine requires an ultra-cold freezer (between minus 112 and minus 76 degrees F) for shipping and storage and is only 31 Tage stable when stored in the refrigerator.

The army vaccine was tested with two shots 28 days apart and also with a third shot six months later.

How does the army vaccine against COVID-19 and other coronaviruses work?

Moderna, Pfizer and Johnson & Johnson’s vaccines all target the specific virus – SARS-CoV-2 – that causes COVID-19. But army scientists have developed their vaccine to protect against future strains of COVID and other coronaviruses.

The Army’s SpFN vaccine is shaped like a soccer ball with 24 faces. Scientists can place the spikes of multiple coronavirus strains on each of the different faces, allowing them to adapt the vaccine for all emerging COVID variants.

“The accelerated emergence of human coronaviruses over the past two decades and the rise of SARS-CoV-2 variants, most recently including Omicron, underscore the ongoing need for next-generation preventive vaccines that provide comprehensive protection against coronavirus disease,” said modjar wheel said in a December statement. “Our strategy was to develop a ‘pan-coronavirus’ vaccine technology that could potentially provide safe, effective and durable protection against multiple coronavirus strains and species.”

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When will the Army’s COVID vaccine be available?

No date has been set. SpFN has successfully completed animal testing and completed Phase 1 human trials in December, but it has yet to complete Phase 2 and 3 human testing when its safety and efficacy are compared to current vaccine options.

Typically, all three phases can take up to five years to complete, but the urgency of the COVID-19 pandemic is accelerating the process. For example, Moderna, Pfizer, and Johnson & Johnson vaccines have all been tested, reviewed, and approved by the Food and Drug Administration over the course of a year.

What Happens Next With The Army’s SpFN Vaccine?

According to a WRAIR spokesperson, “Investigators have devoted their full attention to analyzing the Phase 1 data and writing a report of the results.” The report could come in the next few weeks or even months.

After the data from the phase 1 human studies are published, the phase 2 and 3 studies will begin. So far, there is very little information as to when or how these trials will continue, or if the phases will overlap.

To follow the progress of the Army’s vaccination trials, visit the SpFN COVID-19 Vaccine Tracker bereitgestellt vom US Army Medical Research and Development Command.

For more information on COVID-19, here’s what we know about how the CDC defines being fully vaccinated, how one Save your vaccination record on your phone, and what we don’t know about the virus yet after two years.

The information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified healthcare provider with any questions about a medical condition or health goals.

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