ARV treatment for PLWHA during the COVID-19 pandemic – archyde

Jakarta (ANTARA) – Antiretroviral drugs, or ARVs, are a necessity for patients with HIV-AIDS who are received according to standard criteria for the administration of antiretroviral therapy (ART) to treat HIV infection by inhibiting the growth of the virus.

Also read: Keeping the PLWHA afloat amid the COVID-19 pandemic

It is recommended that patients take this group of drugs for life without interruption, including during the COVID-19 pandemic that has occurred over the past two years.

Dr. Dr. Dr. Hadianti Adlani, Sp.PD-KPTI, said these drugs cannot be separated from side effects, just like drugs used for other therapies.

The effects are both short and long term and therefore need to be monitored by a doctor. Examples of side effects that may occur include anemia, impaired liver function, impaired kidney function, insomnia, hallucinations, and others depending on the type of drug consumed.

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For example, the drug d4T causes preferential neuropathy or damage to the peripheral nervous system, lactic acidosis, which is an excess of lactic acid in the body, and lipodystrophy or conditions due to metabolic complications and impaired fat distribution. ZDV can cause symptoms of anemia, while NVP and EFV can cause hepatitis and rashes.

The ARV administration is divided into first, second and third lines consisting of three combinations of viral anti-replication drug classes, each line having its own administration criteria according to the patient’s condition and stage of disease.

People living with HIV in Indonesia are currently using combination therapy of tenofovir, lamivudine, and efavirenz as their first treatment.

Results of a study by researcher Dwi Retna Susilowati and her colleagues on the efficacy and safety of first-line ARV drugs in HIV-AIDS patients at the Regional General Hospital (RSUD) Ambarawa, Semarang in 2018 showed that the curve survive Therapies with tenovofir, lamivudine, efavirenz have a chance survive the greatest compared to other therapies.

Meanwhile the test results are Tax return Lamivudine and efavirenz showed significant differences in patient survival with tenovofir compared to the other three treatment regimens.

“This means that this regimen has significant efficacy in Indonesia as a first-line therapy option,” Hadianti told ANTARA.

He revealed that research on ARVs to date is being developed and carried out by researchers around the world, particularly with regard to treatments that can kill the HIV virus directly.

Also read: HIV / AIDS campaign in Maluku to fight a pandemic amid a pandemic

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Also read: Risk factors for HIV infection and treatment during the pandemic

Therapy for PLWHA during the pandemic

Hadianti, who practices at Pondok Indah Hospital – Bintaro Jaya, did not deny that some services were actually affected by the COVID-19 pandemic, such as counseling, HIV testing services, antiretroviral therapy, mentoring, laboratory services and radiology.

However, depending on the patient’s immune status, the healthcare provider makes adjustments to services such as online registration, taking medication per month for 2-3 months. The Closed Laboratory Services will try to continue working with other laboratories that are still operating.

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ARVs that must be continuously administered to the PLWHA must ensure the supply of medicines and their smooth distribution in HIV-AIDS service centers throughout Indonesia.

According to him, the empowerment of the service system is based on One-Stop-Service must be optimized with infection protection standards and accessible to all parties involved. Likewise with activities monitoring and evaluation.

Regarding the mechanism for delivering ARV over the past two years, especially for PLWHAs located in the COVID-19 epicenter area, Hadianti said health services for PLWHA are still being provided according to health protocol standards by being safe and secure Comfortable conditions are created for patients who come regularly for treatment.

He said that it is no longer difficult for patients to receive regular treatment as various efforts have been made for patient safety and comfort so that patients can get to the hospital. The demand for telemedicine services has reportedly decreased significantly.

“The obstacle that is still being found is patient concern when the waiting time for doctors and the line for medication in the hospital is long enough. Efforts have been made, however, to arrange the patient’s arrival time at the hospital, ”Hadianti said.

He emphasized that the service for HIV-AIDS patients has so far been functioning normally in compliance with health protocols in accordance with applicable standards and that various efforts to prevent and control infections have been carried out. Laboratory and other services also ran normally and even have increased service times.

Several hospitals, including private clinics, can run HIV-AIDS service programs. For example, Pondok Indah Hospital – Bintaro Jaya is the satellite hospital of South Tangerang City General Hospital, which is the center of HIV-AIDS services in South Tangerang City.

This collaboration is expected to play an important role in providing medicines to HIV-AIDS patients who wish to seek treatment in private hospitals that do not offer ARVs.

ARV itself is included in the state program so that it is not freely traded, but can be obtained free of charge by patients if certain administrative criteria and requirements are met and treated in accordance with the standard. monitoring and evaluation.

About three dollars with Hadianti, a researcher for HPTN 074 as well as an internal medicine specialist, hematology-oncology sub-specialist at the University of Indonesia, Prof. DR. DR. Zubairi Djoerban, SpPD-KHOM, PLWHA also advised not to discontinue the medication.

According to him, people with HIV infection who have even stopped taking the medicine need to start taking medication immediately because regular drug use can improve their quality of life. Currently, the drug is available every three months, but patients must see a doctor while taking the drug.

“Six months of stopping ARV medication can be severe. However, take medication right away. Taking medication regularly improves the quality of life, is productive and helps a lot, ”he said in a recent webinar on the Indonesian Positive Network.

Currently, one of the ARV therapies, namely dolutegrafir, can in principle be used in the event of first-line failure or drug withdrawal. According to Prof. Zubairi, like other drugs, dolutegrafir can have side effects, but these occur very, very rarely.

Therefore, PLWHA who have taken ARVs are advised from the start by doctors not to stop taking medication to treat HIV infection despite the COVID-19 pandemic. ARV is available free of charge as a national program that is fully funded by the government.

Also read: HIV / AIDS cases in Tanjungpinang will rise to 77 people in 2021

Also read: The risk of contracting COVID-19 in PLWHA is the same as in the general population

Also read: New HIV infections in 2020 47 percent lower than in 2010

By Lia Wanadriani Santosa
Editor: Ida Nurcahyani
COPYRIGHT © ANTARA 2021

Reference-www.nach-welt.com

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